CHED Christine Jaworek-Lopes, Irvin Levy, Beatriz Rios-McKee  Wednesday, March 19, 2014 

1538 - Microwave-promoted synthesis of a carbocyclic curcuminoid: An undergraduate organic chemistry laboratory experiment

Joseph J. Mullins, mullinjj@lemoyne.edu, Kathryn Reed, Elizabeth M. Presutto, Allen F. Prusinowski. Department of Chemistry & Physics, Le Moyne College, Syracuse, NY 13214, United States

The microwave-promoted synthesis of a carbocyclic curcuminoid has been adapted from a known method and introduced into the organic chemistry laboratory curriculum. The experiment features several teaching points: microwave irradiation efficiently promotes the reaction; a heating time of only seven minutes (the experiment is suitable for single-reactor microwave units); minimal solvent; rapid and convenient work-up conditions; medicinal properties of curcumin and its analogs; product conjugation (like curcumin, the product exhibits intense orange color); condensation at the less acidic positions of the diketone. Students from multiple lab sections obtained product in high yield and purity. Recent additional developments will be discussed.





Wednesday, March 19, 2014 09:00 AM
Microwave-Promoted Synthesis in the Undergraduate Organic Chemistry Laboratory (08:30 AM - 11:10 AM)
Location: Hyatt Regency Dallas
Room: Reunion Blrm E

 

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