INOR Stephen Koch, Nora Radu  Sunday, March 25, 2012 

266 - Use of 3-methylcatechol as a model compound for urushiol

Andrew Ickes, aickes22@gmail.com, Chelsea Homes, Peter Baran. Department of Chemistry, Juniata College, Huntingdon, PA 16652, United States

Urushiol, an allergen found in poison ivy and several other plants, interacts with skin cell receptors causing an irritation which would otherwise be harmless. Urushiol is a mixture of several dozens of compounds with similar composition featuring 3-substituted catechols. 3-Methylcatechol is a much simpler and cheaper analog of the active components of urushiol and is used in our studies as a model compound for mimicking urushiol. Metal coordination complexes with 3-methylcatechol were studied in order to understand if urushiol can be inactivated before it penetrates the skin. A dark insoluble solid forms when iron(II) and copper(II) salts combine with 3-methylcatechol. In an effort to yield soluble ternary complexes which might inactivate urushiol upon contact and would allow to decontaminate skin, other ligands, such as 2,2'-bipyridine or 1,10-phenanthroline, were included into syntheses. Complexation reactions with natural active components of urushiol obtained directly from the poison ivy plant will also be discussed.


Sunday, March 25, 2012 06:00 PM
Undergraduate Research at the Frontiers of Inorganic Chemistry (06:00 PM - 08:00 PM)
Location: San Diego Convention Center
Room: Hall D

 

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