PHYS Mark Johnson  Wednesday, March 24, 2010 

655 - Comparison of the spectrochemical and physiochemical properties of DNA photolyase and cryptochrome-DASH

Kathleen Paige Sokolowsky1, sokolowk@lafayette.edu, Johannes P.M. Schelvix2, Yvonne M. Gindt1. (1) Chemistry, Lafayette College, Easton, PA 18042, United States, (2) Chemistry, Montclair State University, Montclair, NJ 07043, United States

Both DNA photolyase and cryptochrome-DASH are members of the blue-light photoreceptor family which have the ability to repair cyclobutane pyrimidine dimers (CPDs) in DNA. Interestingly, while photolyase has been reported to repair CPDs in both double-stranded and single-stranded DNA, cryptochrome-DASH has only been reported to repair CPDs in single-stranded DNA. We examine the spectrochemical and physiochemical properties of photolyase and cryptochrome-DASH to better understand the substrate recognition mechanism of each protein.


Wednesday, March 24, 2010 06:00 PM
Physical Chemistry Poster Session (06:00 PM - 07:00 PM)
Location: The Moscone Center
Room: Hall D

 

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