MEDI Jeff Zablocki  Sunday, March 21, 2010 

94 - Progress towards the development of a fluorimetric diagnostic for the early detection of trypanosomatid diseases

Ellen D. Beaulieu, ellen.beaulieu@sri.com, Kenneth J. Gollob, Walderez O. Dutra, Lori L. Olson, Mary J. Tanga. Department of Medicinal Chemistry, SRI International, Menlo Park, CA 94025, United States

We are developing a new point of care diagnostic for the detection of trypanosomatid parasites, based on the fluorimetric detection of a trypanosomal biomarker. Trypanosomal parasites cause three neglected human diseases including Chagas' Disease, Human African Trypanosomiasis, and Leishmaniasis. We are developing a new method for early diagnosis that is based on the detection of a parasite-specific metabolite. Our results show that a unique dye can be used to detect this metabolite from serum extracts by creating a fluorescent molecule upon conjugation suggesting the metabolite may be a good biomarker for the detection of trypanosomal diseases. This diagnostic has several attractive features, including a unique parasitological detection mechanism, low cost, and a low technology detection method that would require minimal technical training. We have synthesized a library of dyes to detect this metabolite and will report our efforts towards developing a diagnostic protocol for the detection of this biomarker.


Sunday, March 21, 2010 07:00 PM
General Poster Session (07:00 PM - 09:00 PM)
Location: The Moscone Center
Room: Hall D

 

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