1028 - Development of a one-pot palladium-catalyzed “borrowed hydrogen” process for the synthesis of substituted amines from nitroarenes and alcohols

Nicholas J Barna, barnan@lafayette.edu, Jennifer L Rutherford, rutherfj@lafayette.edu. Lafayette College, United States

Palladium-catalyzed transfer hydrogenation of nitroarenes to aryl amines has been conducted using an alcohol as the hydrogen source. The resulting in situ-formed aldehyde or ketone then reacts with the aryl amine to form an imine, which can then be further reduced in situ to produce a substituted amine. We report our progress in the development of an efficient catalytic process, as well as our application of this method for the synthesis of indoles.

Monday, March 22, 2010 08:00 PM
Sci-Mix (08:00 PM - 10:00 PM)
Location: The Moscone Center
Room: Hall D

Wednesday, March 24, 2010 07:00 PM
Chemistry for a Sustainable World, Metal-Mediated Reactions & Syntheses, Peptides, Proteins & Amino Acids, New Reactions and Methodology (07:00 PM - 09:00 PM)
Location: The Moscone Center
Room: Hall A